Wheels are provided for Linux, OSX and Windows x86-64, as well as Linx Aarch64, but other machines will have to build the wheel from the source distribution. Building pyrodigal involves compiling Prodigal, which requires a C compiler to be available.


pyrodigal is hosted on GitHub, but the easiest way to install it is to download the latest release from its PyPi repository. It will install all dependencies then install pyrodigal either from a wheel if one is available, or from source after compiling the Cython code :

$ pip install --user pyrodigal


Pronto is also available as a recipe in the bioconda channel. To install, simply use the conda installer:

$ conda install -c bioconda pyrodigal

Arch User Repository

A package recipe for Arch Linux can be found in the Arch User Repository under the name python-pyrodigal. It will always match the latest release from PyPI.

Steps to install on ArchLinux depend on your AUR helper (yaourt, aura, yay, etc.). For aura, you’ll need to run:

$ aura -A python-pyrodigal


Pyrodigal works on Raspberry Pi computers (with NEON vectorization enabled!), and pre-built wheels are compiled for armv7l platforms on piwheels. Run the following command to install these instead of compiling from source:

$ pip3 install pyrodigal --extra-index-url

Check the piwheels documentation for more information.

GitHub + pip

If, for any reason, you prefer to download the library from GitHub, you can clone the repository and install the repository by running (with the admin rights):

$ git clone --recursive
$ pip install --user ./pyrodigal


Keep in mind this will install always try to install the latest commit, which may not even build, so consider using a versioned release instead.

GitHub + setuptools

If you do not want to use pip, you can still clone the repository and run the file manually, although you will need to install the build dependencies (mainly Cython):

$ git clone --recursive
$ cd pyrodigal
$ python build_ext
# python install


Installing packages without pip is strongly discouraged, as they can only be uninstalled manually, and may damage your system.